Publications
Selected Recent Publications
Beyond genomics in Patescibacteria: a trove of unexplored biology packed into ultrasmall bacteria.
Srinivas P, Peterson SB, Gallagher LA, Wang Y, Mougous JD (2024) Beyond genomics in Patescibacteria: a trove of unexplored biology packed into ultrasmall bacteria. PNAS doi: 10.1073/pnas.2419369121
Protein interactions in human pathogens revealed through deep learning
Ian R. Humphreys, Jing Zhang, Minkyung Baek, Yaxi Wang, Aditya Krishnakumar, Jimin Pei, Ivan Anishchenko, Catherine A. Tower, Blake A. Jackson, Thulasi Warrier, Deborah T. Hung, S. Brook Peterson, Joseph D. Mougous, Qian Cong & David Baker (2024) Protein interactions in human pathogens revealed through deep learning. Nature Microbiology doi: 10.1038/s41564-024-01791-x
Streptomyces umbrella toxin particles block hyphal growth of competing species
Qinqin Zhao, Savannah Bertolli, Young-Jun Park, Yongjun Tan, Kevin J. Cutler, Pooja Srinivas, Kyle L. Asfahl, Citlali F. Garcia, Larry A. Gallagher, Yaqiao Li, Yaxi Wang, Devin Coleman-Derr, Frank DiMaio, Dapeng Zhang, S. Brook Peterson, David Veesler & Joseph D. Mougous (2024) Streptomyces umbrella toxin particles block hyphal growth of competing species. Nature doi: 10.1038/s41586-024-07298-z
Genetic manipulation of Patescibacteria provides mechanistic insights into microbial dark matter and the epibiotic lifestyle
Wang Y, Gallagher LA, Andrade PA, Liu A, Humphreys IR, Turkarslan S, Cutler KJ, Arrieta-Ortiz ML, Li Y, Radey MC, Cong Q, Baker D, Baliga NS, Peterson SB, Mougous JD (2023) Genetic manipulation of Patescibacteria provides mechanistic insights into microbial dark matter and the epibiotic lifestyle. Cell doi: 10.1016/j.cell.2023.08.017.
Discovery of a glutathione utilization pathway in Francisella that shows functional divergence between environmental and pathogenic species
Wang Y, Ledvina HE, Tower CA, Kambarev S, Liu E, Charity JC, Kreuk LSM, Tang Q, Chen Q, Gallagher LA, Radey MC, Rerolle GF, Li Y, Penewit KM, Turkarslan S, Skerrett SJ, Salipante SJ, Baliga NS, Woodward JJ, Dove SL, Peterson SB, Celli J, Mougous JD (2023) Discovery of a glutathione utilization pathway in Francisella that shows functional divergence between environmental and pathogenic species. Cell Host & Microbe doi: 10.1016/j.chom.2023.06.010.
Omnipose: a high-precision, morphology-independent solution for bacterial cell segmentation
Cutler KJ, Stringer C, Lo TW, Rappez L, Stroustrup N, Peterson SB, Wiggins PA, Mougous JD (2022) Omnipose: a high-precision, morphology-independent solution for bacterial cell segmentation. Nature Methods doi: 10.1038/s41592-022-01639-4.
Genome-wide protein-DNA interaction site mapping using a double strand DNA-specific cytosine deaminase
Gallagher LA, Velazquez E, Peterson SB, Charity JC, Radey MC, Gebhardt MJ, Hsu F, Shull LM, Cutler KJ, Macareno K, de Moraes MH, Penewit KM, Kim J, Andrade PA, LaFramboise T, Salipante SJ, Reniere ML, de Lorenzo V, Wiggins PA, Dove SL, Mougous JD (2022) Genome-wide protein–DNA interaction site mapping in bacteria using a double-stranded DNA-specific cytosine deaminase. Nature Microbiology doi: 10.1038/s41564-022-01133-9.
Discovery of coordinately regulated pathways that provide innate protection against interbacterial antagonism
Ting S, LaCourse KD, Ledvina HL, Zhang R, Radey MC, Kulasekara HD, Somavanshi R, Bertolli SK, Gallagher LA, Kim J, Penewit KM, Salipante SJ, Xu L, Peterson SB, Mougous JD (2022) Discovery of coordinately regulated pathways that provide innate protection against interbacterial antagonism. eLife doi: 10.7554/eLife.74658.